The role of ghrelins Essay Example for Free

The role of ghrelins Essay Ghrelin is a general name for a class of hormones found in the gastrointestinal tract of vertebrates. It is a preprohormone containing a chain of 28 amino acid peptides. During synthesis, a modification arises whereas n-octanoic acid is bound to one of its amino acids. This makes it capable of playing its biological role. Ghrelins are synthesized at the fundus lining the stomach. It is primarily produced by epithelial cells lining the fundus. However, smaller amounts have also been detected in the kidneys, placenta, hypothalamus and the pituitary gland. (Brown, 2006) The ghrelin receptor was known before the discovery of ghrelin. It is located in the anterior pituitary and stimulates secretion of growth hormone when activated. It was named GHS-R or growth hormone secretagoue receptor. In 1999, Kojima et al. announced that they have discovered the natural ligand for GHS-R.   They named it ghrelin, deriving it form the word â€Å"ghre† which means grow in Proto-Indo-European languages. They obtained it from rat stomach and investigated its role in pituitary growth hormone and energy homeostasis functions. (Kojima Kangawa, 2004) Roles of ghrelin Ghrelin is the ligand of GHS-r. Its signal together with that of semostatin and other growth hormone inducers control the timing as well as the magnitude of growth hormone excretion. It is suggested that the stomach releases ghrelin into the bloodstream, where it is conveyed to the potiuitary gland, triggering the release of growth hormone. Kanagawa et al. found significant amounts of ghrelin in healthy people.(Kojima et al., 1999) In 2000, Ezio Ghigo et al. discovered that ghrelin injections led to prolonged increase of growth hormone concentrations in the blood. (Dickson, 1999)   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Ghrelin   also seems to stimulate appetite. Lab tests in rats show ann increase in body weight after ghrelin injections. This effect is independent of ghrelin’s role in GH stimulation. In people, a popular side effect of taking ghrelin containing drugs was the sensation of intense hunger. About 80% of test participants in a study to test ghrelins growth hormone functions also suffered an increase of appetite. It was found that ghrelin concentration in the blood increases as a person grows hungry and decreases as that person’s hunger is sated.   Another study showed that people injected with ghrelin before meals increased their food intake by 30%. (Cummings et al., 2002) Another study also showed that resting   ghrelin levels rise as net body weight decreases and returns once a set point is reached. This means that the body regulates ghrelin levels based on a specific body weight attainment, making you hungrier as you lose more weight. Persons with anorexia nervosa, a disorder in which people starve themselves show extremely high amounts of ghrelin. But it seems in their cases, their body does not listen. (Travis, 2002)The increase of ghrelins is also related to time as discovered by Yildiz et al. An increase in ghrelin was noted between midnight to dawn, mhowever, hunger is suppressed by other hormones, making it easier to fall asleep and eat in the morning after.(Yildiz, Suchard, Wong, McCann, Licinio, 2004)Alos, lack of sleep particularly in obese persons lead to production of ghrelin and less production of leptin, the hormone which suppresses appetite. Ghrelin levels also decrease dramatically with the conduction of gastric bypass surgery. Animal research has also discovered that ghrelin may enhance memory and learning as it enters the hippocampus via the bloodstream. High ghrelin levels, particularly before meals when the stomach is empty may be the time most conducive to learning. (Philips, 2006) REFERENCES Brown, R. (2006). Ghrelin.  Ã‚   Retrieved March 11, 2007, from http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/gi/ghrelin.html Cummings, D., Weigle, D., Frayo, R., Breen, P., Ma, M., Dellinger, E., et al. (2002). Plasma Ghrelin Levels after Diet-Induced Weight Loss or Gastric Bypass Surgery. New England Journal of Medicine(346), 1623-1630. Dickson, S. L. (1999). Ghrelin: A newly discovered hormone  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   [Electronic Version]. British Society for Neuroenterology from http://neuroendo.org.uk/index.php/content/view/26/11/. Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., Kangawa, K. (1999). Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402, 656-660 (402), 656-660. Kojima, M., Kangawa, K. (2004). Ghrelin: Structure and Function   [Electronic Version]. Physiological Review, 85, 495-522. Retrieved March 11 2007. Philips, M. L. (2006). Hunger hormone tied to learning [Electronic Version]. The Scientist. Retrieved March 11 2007 from http://www.the-scientist.com/news/display/23132/. Travis, J. (2002). The Hunger Hormone? [Electronic Version]. Science News Online, 161, 107. Retrieved March 11 2007 from http://www.sciencenews.org/articles/20020216/bob10.asp. Yildiz, B. O., Suchard, M. A., Wong, M.-L., McCann, S. M., Licinio, J. (2004). Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity [Electronic Version]. Medical Sciences. Retrieved March 11 2007 from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=478601.

Baldwins Writing Style in Notes to a Native Son Essay -- James Baldwi

Father and Son: Bad to Regrettable James Baldwin is known to be one of the best essay writers in the twentieth century who wrote on a few topics including race, discrimination, sexuality and most of all his personal experiences. In â€Å"Notes of a Native Son†, he uses two main strategies to get his point across. First, he likes to tell a story in a narrative view. Following is normally his analysis of the event. He describes the event and then gives his theory on the matter. By doing this, he grants the reader a chance to decipher the meaning. His interpretation may not be what the reader’s is. He likes to argue and provides the basis for his argument in â€Å"Notes of a Native Son†. Throughout the essay he talks about himself and his father, their relationship and how their interactions influence his final feelings toward his father. He also integrates public incidents during those times into the essay. This method presents the reader with an opportunity to understand the race issue at that tim e. This essay is about part of his life. In the beginning he starts with his father’s death. It was coincidental that the funeral was on his Baldwin’s nineteenth birthday. Mr. Baldwin, his father, and his wife conceived a child near the end of his life. This child was born a few hours after his death. Here Baldwin presents a binary of life and death, along with other examples, that he executes throughout the essay. In retrospection, he perceives his father’s death as a time of sadness and regrets not having a healthier rapport with him and he mentions that his siblings are happy that their father will never come home again. He tells us about the race riots in Detroit and New Jersey and criticizes afterwards. These happenings show the influen... ...art. Baldwin does this using his own personal experiences and tying them into the greater picture of society. All the stories he has expressed in â€Å"Notes of a Native Son† can be paralleled with what was going on during that period. He even explained the riots in that sense for the reader. In the first paragraph he states that they drove his father to the cemetery over smashed plate glass (63). This was a result of the hatred and despair felt by the rioters. This visual is a representation of the hatred that had helped to kill his father. The abhorrence that played a role in the death of his father, he feared would do the same to him. The end of the essay shows Baldwin letting go of this hatred and despair. Works Cited Baldwin, James. â€Å"Notes of a Native Son.† 1995. James Baldwin: Collected Essays. Ed. Toni Morrison. New York: Library of America, 1998. 63-84.

Prescription Drug Abuse Essay

Millions of people throughout the world are taking drugs on a daily basis. If you were to ask someone why they take prescription drugs, most people would be taking them for the right reason. However, it’s estimated that twenty percent of people in the United States alone have used prescription drugs for non-medical reasons.1 Prescription drug abuse is a serious and growing problem that often goes unnoticed. Abusing these drugs can often lead to addiction and even death. You can develop an addiction to certain drugs that may include: narcotic painkillers, sedatives, tranquilizers, and stimulants. Prescription drugs are the most common abused category of drugs, right next to marijuana, cocaine, heroin, and other dangerous drugs. The centers for Disease Control and Prevention have classified prescription drug abuse as an epidemic. Addressing the prescription drug abuse epidemic could help build stronger communities and allow those with substance abuse disorders to lead healthier, more satisfying lives. A crucial step in overcoming the problem of prescription drug abuse is to first educate parents, youth, and patients, about the dangers of abusing these drugs. Studies have shown that most people who misuse these drugs are teens and young adults ages twelve to twenty five. They may often believe these substances are safer than illicit drugs because they were prescribed by a professional. The National Survey on Drug Use and Health shows that nearly a third of people age twelve and over used drugs for the first time by using a prescription drug non-medically. In a study of students in Wisconsin and Minnesota, thirty four percent of kids diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) said they had been approached to sell or trade their Ritalin or Adderall. The latest National Survey on Drug Use and Health shows that over seventy percent of people who abused prescription pain relievers got them from friends or relatives. Most people do not lock up their medication or discard them when they no longer intend on using them. This makes them vulnerable to theft or misuse. According to the 2012 Monitoring the Future Survey, about fifty percent of high school seniors said that opioid drugs, other than heroin (e.g., Vicodin), would be fairly easy to obtain. Interestingly, boys and girls tend to misuse these drugs for different reasons. For example, boys are more likely to abuse stimulants  to get high. Girls tend to abuse them to lose weight. Those who abuse prescription medications are more likely to report use of other drugs unl ess this issue is taken into control. Many different things can happen when you abuse prescription drugs. Stimulant abuse can cause paranoia, dangerously high body temperatures, and irregular heartbeat. Abuse of opioids can cause drowsiness, nausea, constipation, and slowed breathing. Abusing depressants can cause slurred speech, shallow breathing, fatigue, disorientation, lack of coordination, and seizures. Abusing over the counter drugs can impair motor functions, produce numbness, cause nausea and vomiting, and increase heart rate.4 Doctors consider the risks to each patient before prescribing medications. They take into account things like the patient’s age, weight, medical history, the drugs form, dose, possible side effects, and the potential for addiction. People abusing drugs might not understand how these factors interact and can put them at risk. Someone abusing a certain type of medication may overload their system or make themselves vulnerable to dangerous drug interactions that can cause seizures, coma, or even death. In 2000, about forty three percent of hospital emergency admissions for drug overdose happened because of misused prescription drugs. They are designed to treat a particular illness or condition, but they often have other side effects on the body. For example, stimulants such as Adderall increase attention but also raise blood pressure and heart rate. Th ese side effects can be worse when prescriptions are not taken as prescribed, or are abused in combination with other substances. For instance, some people mix alcohol and Valium, both of which can slow breathing. The combination of the two could stop breathing altogether. Cough and cold medications are some of the most commonly abused over the counter medications. They contain an ingredient called dextromethorphan. However, to get to the â€Å"high† craved by people who use drugs, large quantities are needed. At high doses, dextromethorphan causes side effects similar to those of the drugs Ketamine, or PCP, by affecting similar sites to the brain. Ketamine and PCP are considered â€Å"dissociative† drugs, which make people feel disconnected from their normal selves. When taken as directed, over the counter drugs are safe and effective, but high doses can cause problems. It’s always important to read the bottle labels and take over the counter medications only as directed. Not all prescription drugs have the potential for abuse and  addiction. Many drugs don’t even act in the brain. For example, antibiotics are not addictive. On the rare occasion people who take drugs for medical conditions may become addicted. This is why it is extremely important to be under a doctor’s care while taking prescription medication. Most prescription drugs are taken in a form th at gets to the brain slowly at a dose that treats a problem, but doesn’t overwhelm the system. Both of which reduce the likelihood of an addiction. Long-term medical use of prescription drugs can lead to physical dependence, because the brain and the body naturally adapt to chronic drug exposure. A person may need larger doses of the drug to achieve the same initial effects, which is known as tolerance. When drug use is stopped, withdrawal symptoms can occur. Dependence is not the same as addiction. It is one of the many reasons a person should only take and stop taking prescription drugs under a physician’s care. The risks for addiction increase when drugs are used in ways other than prescribed. Physicians, their patients, and pharmacists all play a role in identifying and preventing prescription drug abuse. More than eighty percent of Americans had contact with a healthcare professional in the past year, placing doctors in a position not only to prescribe medications, but also to identify abuse. By asking about all drugs, physicians can help their patients recognize that a problem exists, set recovery goals, and seek appropriate treatment. Screening for prescription drug abuse can also be incorporated into routine medical visits. Doctors should take note of rapid inc reases in the amount of medication needed and unscheduled refill requests. Patients can also take steps to ensure that they use prescription drugs appropriately. These steps include always following the drugs directions, being aware of potential interactions with other drugs, never stop or change a dosing regimen without first discussing it with a healthcare provider, and never use another person’s prescription. Patients should always inform their healthcare professionals about all prescriptions, over the counter medications, and dietary or herbal supplements they are taking before they obtain any other medication. Pharmacists also play a very important role in preventing drug abuse. Pharmacists dispense medications and can help patients understand the directions for taking them. By being watchful for prescription falsifications or alterations, pharmacists can serve as the first line of defense in recognizing  prescription drug abuse. Some pharmacies have developed hotlines to alert other pharmacies in the region when a fraudulent prescription is detected. Prescription drug monitoring programs (PDMPs) require physicians and pharmacists to log each filled prescription into a State database. This can assist medical professionals in identifying patients who are getting prescriptions from multiple sources. Because prescription drugs are legal, they are easily accessible. Parents, law enforcement, the medical community, and all levels of government have a role to play in reducing prescription drug abuse. Some things you can do to reduce the abuse of drugs may include: Follow disposal guidelines, talk to your children, and seek treatment or support individuals in recovery. By following the guidelines you reduce the risk of unintentional diversion or harm. Talking to your children at an early age can make sure they know the dangers of drug abuse and can be very helpful in prevention. It is always very important to encourage someone you may know with a drug abuse problem to seek recovery. Thousands of individuals who have struggled with addiction are now living happy lives with the help of treatment and recovery services.2 In conclusion, prescription drug abuse is a growing problem that can be overcome with prevention and the right treatment. References 1. Prescription Drug Abuse. Medline Plus. Available at: www.nlm.nih.gov/medlineplus/prescriptiondrugabuse.html Accessed 9/20/2013 2. Prescription Drug Abuse. Office of National Drug Control Policy. Available at: www.whitehouse.gov/andcp/prescription-drug-abuse Accessed 9/20/2013 3. Prescription Drug Abuse and Addiction. CRC Health Group. Available at: www.crchealth.com/addiction/prescription-drug-addictions-2/ Accessed 9/20/2013 4. Drug Facts-Prescription Drugs. NIDA For Teens. The Science behind Drug Abuse. Available at: www.teens.drugabuse.gov/drug-facts/prescription-drugs Accessed 9/20/2013 5. Prescription Drugs: Abuse and Addiction. National Institute on Drug Abuse. Available at: www.drugabuse.gov/publications/prescription-drugs-abuse-addiction/preventing-recognizing-prescription-drug-abuse Accessed 9/20/2013 6. The Prescription Drug Abuse Epidemic. PDMP Center of Excellence. Available at: www.pdmpexcellence.org/drug-abuse-epidemic Accessed 9/20/2013

Questions On Information Security And Protection Essay

This paper surveys a scope of ebb and flow MIS inquire about writing to recognize investigate subjects in data security and protection. Aftereffects of this study show IT security gives the premise of flow research in the zone of data security and protection. The aftereffects of this study uncover constrained research here, especially at the authoritative level. One conclusion is that this absence of research results from authoritative unwillingness to share data also, insights on security. Another conclusion is that exploration is required in the range of data security. One region of future research might be authoritative security approaches. Two specific ranges of intrigue might be client discernments of security approaches and pick in/quit arrangements and strategies. Also, investigate identified with people s sympathy toward data protection might be less hazardous to think about than hierarchical security issues. Inquire about in this region is vital in light of the fact that cli ent sympathy toward data security can possibly influence the eventual fate of ecommerce. Introduction: Information security is the vital issue now a days. This paper reports on a structured review of a range of current MIS research literature undertaken to identify the nature of recent study in information security and privacy. The purpose of this review is to classify and analyze studies from this stream of research and identify today’s hot topics in information security and privacy in anShow MoreRelatedWhat Are The Behaviors That Influence Information Security Compliance And Attitudes Toward Compliance In The Public School System?1723 Words   |  7 Pagesadministrators may consider prioritizing the need for information security training to avoid disclosure of information from both students and teachers. 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